FlixBus operates a bus from Dresden central station to Brno 4 times a day. Tickets cost 650 Kč - 950 Kč and the journey takes 4h 20m. Alternatively, you can take a train from Dresden Hbf to Brno via Praha Hlavni Nadrazi and Prague Central Train Station Wilsonova in around 5h 50m. Train operators. RegioJet. Swiss Railways (SBB/CFF/FFS) EuroNight.

It takes an average of 3h 5m to travel from Dresden Hbf to Prague by train, over a distance of around 73 miles (118 km). There are normally 18 trains per day travelling from Dresden Hbf to Prague and tickets for this journey start from £17.21 when you book in advance. First train.

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